Hematopathology - Morphology, Immunophenotype, Molecular Pathology, Clinical Integration and Disease

Autor: MD Aydin Nizami

Editorial: A.M

Año: 09/10/2026

ISBN: 9784163479460

Encuadernación: Tapa blanda

Páginas: 500 pp.

Idioma: eng

EAN: 9784163479460

A difficult hematopathology case rarely becomes clear from a single finding. The decisive answer often lies in understanding how the morphology, immunophenotype, molecular findings, tissue architecture, and clinical context fit together.
Hematopathology: An Integrated Approach to Diagnosis and Disease Biology provides a rigorous framework for the diagnosis and biological understanding of hematolymphoid neoplasms and related disorders, integrating morphology, immunophenotype, molecular pathology, cytogenetics, tissue architecture, clinical context, and disease evolution.
The book focuses on diagnostic reasoning rather than memorization. It explains how to establish cellular lineage and differentiation, recognize abnormal morphology, interpret immunophenotypic patterns, evaluate molecular and cytogenetic findings, construct meaningful differentials, resolve discordant results, and determine when individual findings are disease-defining, supportive, exclusionary, or nonspecific.
Major myeloid, lymphoid, plasma-cell, histiocytic, dendritic, and related disorders are approached through their biological basis, morphologic expression, immunophenotypic identity, molecular characteristics, clinical context, diagnostic criteria, prognosis, and evolution. Particular emphasis is placed on clonal hematopoiesis, neoplastic transformation, clonal evolution, therapeutic selection, measurable residual disease, and disease monitoring.
Contemporary approaches including digital pathology, computational image analysis, artificial intelligence, spatial technologies, single-cell analysis, and multi-omic, profiling, are considered in the context of their diagnostic evidence, limitations, validation, and clinical utility.
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